TB-500 (Thymosin Beta-4) 10mg

TB-500 Research Overview

TB-500 is an N-terminal acetylated peptide fragment corresponding to amino acids 17–23 of thymosin beta-4. Its sequence is commonly represented as Ac-LKKTETQ.

Laboratory research has examined the peptide’s chemical characterization, metabolism, analytical detection, and activity in cell-based research models. Research involving full-length thymosin beta-4 may provide relevant background, but its findings cannot automatically be attributed to TB-500.

TB-500 Research Areas

Analytical Characterization

Researchers have developed mass-spectrometry methods for identifying and quantifying TB-500 and its metabolites. These methods are relevant to peptide characterization, metabolism studies, and analytical testing. (PMID: 38382158).

Metabolism Research

A 2024 study evaluated TB-500 using human serum, in-vitro enzyme systems, and samples from rats. Researchers identified several metabolites and examined how long selected metabolites remained detectable in the experimental model. (PMID: 17495252).

Cell-Migration Research Models

The same study screened TB-500 and its metabolites using an in-vitro fibroblast assay. The results indicated that one metabolite, Ac-LKKTE, demonstrated significant activity in that particular assay, while the authors noted that previously reported activity may be associated with a metabolite rather than the parent TB-500 peptide. (PMID: 34280397).

These laboratory findings do not establish wound-healing or tissue-repair effects in humans.

Sports-Testing Research

TB-500 has also been studied in the context of analytical detection and prohibited-substance testing. Published research includes methods for characterizing the peptide and examining adsorption effects that can influence laboratory analysis.

Peer-Reviewed Studies 

• Synthesis and characterization of the N‐terminal acetylated 17‐23 fragment of thymosin beta 4 identified in TB‐500, a product suspected to possess doping potential

Esposito, S., Deventer, K., Goeman, J., Van der Eycken, J., & Van Eenoo, P. (2012)

Drug testing and analysis, 4(9), 733-738.

• Adsorption effects of the doping relevant peptides Insulin Lispro, Synachten, TB-500 and GHRP 5

Judák, P., Van Eenoo, P., & Deventer, K. (2017)

Analytical biochemistry, 537, 69-71.

Structure

Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu­lle-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr­Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu­Thr-lle-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser Molecular formula: C212H350N5s01aS
Molar Mass: 4963.4408
CAS number: 77591-33-4
PubChem: CID 16132341